Benefits and beneficiaries
Selected references
AIMS of the project
Project Workplan
Concerted actions
Scientific publications
Selected references on prior art

Sandbäck-Pikas, D.S., Li, J.-p, Vlodavsky, I., and Lindahl, U. (1998) Substrate specificity of heparanases from human hepatoma and platelets,  J. Biol. Chem. 273, 18770-18777

Vlodavsky, I., and  Friedmann, Y. (2001) Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J. Clin. Invest., 108, 341-347

Parish, C.R., Freeman, C., and Hulett, M.D. (2001) Heparanase: a key enzyme involved in cell invasion. Biochim. Biophys. Acta, 1471, M99-M108

Casu, B., and Lindahl, U. (2001) Structure and biological interactions of heparin and heparan sulfate. Adv. Carbohydr. Chem. Biochem. 57, 159-208

Okada, Y., Yamada, S., Toyoshima, M., Domg, J., Nakajima, M., and Sugahara, K. (2002) Structural recognition of recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence J. Biol. Chem. 277, 42488-42495

McKenzie, E., Young, K., Hircock, M., Bennett, J., Bhaman, M., Felix, R., Turner, P., Stamps, A., McMillan, D., Saville, G. et al. (2003). Biochemical characterisation of the active heterodimer form of human heparanase protein expressed in insect cells. Biochem. J. 373, 423-435

Levy-Adam, F., Miao, H. Q., Heinrikson, R. L., Vlodavsky I., and Ilan, N. (2003). Heterodimer formation is essential for heparanase enzymatic activity. Biochim. Biophys. Res. Comm. 308, 885-891

Casu, B., Guerrini, M., Guglieri, S., Naggi, A., Perez, M., Torri, G., Cassinelli, G., Ribatti, D., Carminati, P., Giannini, G., Penco, S., Pisano, C., Belleri, M., Rusnati, M, and Presta, M. (2004) Undersulfated and glycol-split heparins endowed with antiangiogenic activity J. Med. Chem 47, 838-848

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